ParkinsonCanadaV1, Main, Exploration, bibRecord, 003058

Role of serotonin2C receptors in the control of brain dopaminergic function

Identifieur interne : 003058 ( Main/Exploration ); précédent : 003057; suivant : 003059

Role of serotonin2C receptors in the control of brain dopaminergic function

Auteurs : Vincenzo Di Matteo [Italie] ; Marisa Cacchio [Italie] ; Camillo Di Giulio [Italie] ; Ennio Esposito [Italie]

Source :

Pharmacology, biochemistry and behavior [ 0091-3057 ] ; 2002.

RBID : Pascal:02-0355643

Descripteurs français

Pascal (Inist)
- Récepteur sérotoninergique 5-HT2C, Rat, Homme, Etat dépressif, In vitro, In vivo, Schizophrénie, Parkinson maladie, Dépendance, Article synthèse, Sérotonine, Voie dopaminergique, Encéphale, Dopamine, Antagoniste, Agoniste, Système nerveux central, Aire tegmentaire ventrale, Locus niger, Voie nigrostriatale, Neuroleptique, Psychotrope, Animal, Voie mésolimbique, Antidépresseur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- 5-HT2C serotonin receptor, Agonist, Animal, Antagonist, Antidepressant agent, Brain (vertebrata), Central nervous system, Dependence, Depression, Dopamine, Dopaminergic pathway, Human, In vitro, In vivo, Locus niger, Mesolimbic pathway, Neuroleptic, Nigrostriatal pathway, Parkinson disease, Psychotropic, Rat, Review, Schizophrenia, Serotonin, Ventral tegmental area.

Abstract

There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin_2C (5-HT_2C) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT_2C receptor agonists decrease, while 5-HT_2C receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT_2C receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT_2C receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000B74
to stream PascalFrancis, to step Curation: 000149
to stream PascalFrancis, to step Checkpoint: 000993
to stream Main, to step Merge: 003502
to stream Main, to step Curation: 003058

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin<sub>2C</sub>
 (5-HT<sub>2C</sub>
) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT<sub>2C</sub>
 receptor agonists decrease, while 5-HT<sub>2C</sub>
 receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT<sub>2C</sub>
 receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT<sub>2C</sub>
 receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.</div>
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Role of serotonin2C receptors in the control of brain dopaminergic function

Role of serotonin2C receptors in the control of brain dopaminergic function

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri